Arthritis Information and  MSM  Supplement Center.

What Can MSM Do For You

Every few years a new supplement or vitamin will magically popup and promise to be the cure-all people seek for a variety of easy fixes and secret cures. MSM is sulfur; in its purest form, you find amazing results but not magical results.

MSM and seasonal allergies

A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane MSM in the treatment of seasonal allergic rhinitis.

J Altern Complement Med. 2002 Apr;8(2):167-73. Barrager E,. GENESIS Center for Integrative Medicine, Graham, WA.

Numerous clinical observations and case studies have led researchers to hypothesize that MSM may reduce the symptoms associated with seasonal allergic rhinitis. The primary goal of this study was to evaluate the efficacy of MSM in the reduction of seasonal allergic rhinitis associated symptoms. Fifty subjects consumed 2,600 mg of MSM supplement orally per day for 30 days. Clinical respiratory symptoms and energy levels were evaluated by a Seasonal Allergy Symptom Questionnaire (SASQ) at baseline and on days 7, 14, 21, and 30. Immune and inflammatory reactions were measured by plasma immunoglobulin E (IgE) and C-reactive protein at baseline and on day 30. An additional inflammatory biomarker, plasma histamine, was measured in a subset of subjects (n = 5). Day 7 upper and total respiratory symptoms were reduced significantly from baseline. Lower respiratory symptoms were significantly improved from baseline by week 3. All respiratory improvements were maintained through the 30-day visit. Energy levels increased significantly by day 14; this increase continued through day 30. No significant changes were observed in plasma IgE or histamine levels. The results of this study suggest that MSM supplementation of 2,600 mg/day for 30 days may be helpful in the reduction of symptoms associated with seasonal allergic rhinitis.

MSM and cancer

Aspirin and methylsulfonylmethane (MSM): a search for common mechanisms, with implications for cancer prevention.

Anticancer Res. 2003 Jan-Feb;23(1A):453-8.

Aspirin (acetylsalicylic acid), a prototypic nonsteroidal anti-inflammatory drug (NSAID), and MSM, a "nutritional supplement", are both used in the treatment of arthritis and described as cancer chemopreventive agents. Initial experimentation indicating that aspirin and MSM also induced the differentiation of murine erythroleukemia cells led to a search for common mechanisms involving these two agents. Since the major mechanism of action attributed to aspirin is the inhibition of cyclooxygenase (COX), prostaglandin production was examined under differentiation-inducing conditions in murine erythroleukemia cells. Aspirin at low, nontoxic concentrations induced differentiation leading to terminal cell division. Aspirin had no effect on PGE2 production and minimal inhibitory effect on COX activity. Furthermore, salicylate, a major metabolite of aspirin and an ineffective COX inhibitor, induced differentiation at concentrations comparable to aspirin. Similar experiments with MSM indicated that MSM had no effect on PGE2 production or on COX activity under differentiation--inducing conditions and at concentrations reported in other studies. These experiments indicated that aspirin and MSM induced differentiation by a COX-independent mechanism(s) and suggested that a common mechanism for the chemopreventive action invoked by both agents might be the activation of gene functions leading to differentiation and thereby dismantling the cellular capacity for proliferation.


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Disclaimer: The information provided to you in this website has been compiled from numerous journals, research papers and studies for the sole purpose of offering consumers and professionals like you information about our MSM products.  None of the information herein should be construed as a claim for cure, prevention or treatment of any disease.  The statements in this website may be produced in any manner for public or private use without written consent from Arthritis MSM Supplements, Inc.  1-800-903-0309.  Copyright 2001.  The above statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.